Transcendence

Description
The change is be applied when first picked up. You may change your Max HP afterwards via other means. By itself, the  loss is reduced from 40% to 25%.

Strategy and Synergy

 * As you lose after shuffling, the  gain can dwindle very quickly, especially in smaller decks.
 * stacks with and is highly recommended.
 * You're also completely vulnerable to and  damage, which ignores Shields.
 * Try to take this as a last resort if you're low on HP, like you would with.
 * Shopkeeper's overwrites the  change, but her current HP is still set to 1.
 * Be warned that taking any artifacts that reduce your below 1 will instantly kill you.
 * You can regain via, , the  upgrade, and pacts.